2017 – Biological and antioxidant activity of Gunnera tinctoria (Nalca)

The endemic Chilean edible plant Gunnera tinctoria (Nalca) is highly appreciated in the south of Chile by the small farmers. Nevertheless, no background exists about his secondary metabolites. In the present study, in the leaf from G. tinctoria was investigated the content of bioactive compounds like coumaric acid, ascorbic acid and total phenols; the antioxidant capacity was evaluated by 3-ethylbenzothiazoline-6-suslfonic acid (ABTS), oxygen radical absorbance capacity (ORAC), ferric reducing antioxidant power), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods reducing sugars were measured. Finally, the biological activity was evaluated against Cladophialophora and Cryptococcus laurentii. The results suggest that the most abundant constituent in the extract were catechin (1344.97 mg/100 g dry weight) and epicatechin (1429.28 mg/100g dry weight), and was confirmed and quantified by high performance liquid chromatografy (HPLC-PDA); while the ORAC methodology showed a high antioxidant capacity (192000.0±5.91 umol Trolox Eq/100 g dry weight). On the other hand, the extract had a fungicide effect against both microorganism assayed, inhibiting the growth of Cladophialophora´s mold- and the yeast Cryptococcus laurentii. This is the first report of antioxidant capacity, bioactive compounds and biological activity of G. tinctoria, and these findings suggest that an extract prepared from the Nalca leaf may be a promising source of antioxidant and bioactive compounds and as a research object by being an antifungal and therapeutic alternative in development.

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4 comentarios en “2017 – Biological and antioxidant activity of Gunnera tinctoria (Nalca)

  • Excelente articulo, es un tema muy interesante. Representa la medicina del mañana.
    El extracto de la hoja de Nalca solo presenta actividad antifungica solo en la especie Cryptococcus laurentii. ¿O, también podría presentar la misma actividad para C. neoformans y C. gattii?

    Saludos desde Ecuador.

    • Estimada Diana, no lo utilizamos en estos agentes porque el objetivo del trabajo fue utilizar el extracto en hongos aislados de salas de maduración de quesos, pero potencialmente podría servir, saludos

    • Estimado Hernán no tengo conocimiento sobre la actividad antifúngica de Schizophyllum commune, pero si he leído que se ha utilizado para mejorar el sistema inmune de pacientes inmunosuprimidos por mejorar la respuesta TH1, saludos

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