Ephedra chilensis K Presl, known locally as pingo–pingo, is a Chilean endemic plant used in traditional medicine as an anti-inflammatory and used in other treatments. However, unlike for the other Ephedra species, there have been no reports on the antioxidant and cytotoxic effects of this plant. The present study aims to explore the potential applications of E. chilensis extract as Leer más2019 – In vitro antioxidant and antiproliferative effect of the extracts of Ephedra chilensis K Presl aerial parts[…]

The resinous exudates from Escallonia illinita by products was characterized by FT-IR, NMR and HRMS. Six compounds were isolated and identified as follows: 1,5-diphenylpent-1-en-3-one (1), 4-(5-hydroxy-3,7-dimethoxy-4-oxo-4H-chromen-2-yl)phenyl acetate (2), pinocembrin (3), kaempferol 3-O-methylether (4), (3S,5S)-(E)-1,7-diphenylhept-1-ene-3,5-diol (5) and the new diarylheptanoid (3S,5S)-(E)-5-hydroxy-1,7-diphenylhept-1-en-3-yl acetate (6). The anti-oomycete potential of the resinous exudate, as well as the main compounds, was tested Leer más2019 – Isolation and identification of compounds from the resinous exudate of Escallonia illinita Presl. and their anti?oomycete activity[…]

The antibacterial activity against Staphylococcus aureus of aerogels fabricated from colloidal suspensions of chitosan/chondroitin sulfate nanocomplexes is analyzed. Upon freeze-drying the colloidal suspensions, the aerogels presented a porous structure made of microsheets and microfibers. The aerogels could, in addition, be loaded with antimicrobial agents. Loaded with the antibiotic erythromycin, the aerogels showed crystalline deposits, affecting the topography Leer más2018 – Antibacterial activity against Staphylococcus aureus of chitosan/chondroitin sulfate nanocomplex aerogels alone and enriched with erythromycin and elephant garlic (Allium ampeloprasum L. var. ampeloprasum) extract[…]

Here, we highlight the potential of aromatic charged polymer/dye complexes as candidates to integer new functional formulations and materials with specific characteristics given by complexation through aromatic-aromatic interactions. Highly porous sponges made of alginate as main structural component and containing poly(sodium 4-styrenesulfonate)/methylene blue complexes have been synthesized by freeze-drying aqueous mixtures of the three components. The aromatic polyelectrolyte allowed controlling the Leer más2017 – Photodynamic action of methylene blue subjected to aromatic-aromatic interactions with poly(sodium 4-styrenesulfonate) in solution and supported in solid, highly porous alginate sponges[…]

Introducción: La epidemiología de la candidemia en Chile es poco conocida, a pesar de ser una enfermedad frecuente y grave. Objetivos: Analizar la incidencia y perfil de susceptibilidad in vitro de especies del género Candida causantes de candidemia en el Hospital Base Valdivia. Material y Métodos: Se identificó todos los casos de candidemia ocurridos en la institución entre Leer más2017 – Epidemiología y susceptibilidad antifúngica de especies causantes de candidemia en la ciudad de Valdivia, Chile.[…]

An efficient synthesis of a series of 4?-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by 1H-NMR, 13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against Leer más2017 – Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin[…]

The endemic Chilean edible plant Gunnera tinctoria (Nalca) is highly appreciated in the south of Chile by the small farmers. Nevertheless, no background exists about his secondary metabolites. In the present study, in the leaf from G. tinctoria was investigated the content of bioactive compounds like coumaric acid, ascorbic acid and total phenols; the antioxidant Leer más2017 – Biological and antioxidant activity of Gunnera tinctoria (Nalca)[…]

Introducción: Las tinciones cromógenas o “Black Stain” (BS) se han asociado a una baja experiencia de caries y un menor recuento de bacterias cariogénicas. El objetivo es determinar si existe diferencia en el número de pacientes que presenten un alto recuento de S. mutans (>105 UFC/ml saliva) entre niños con BS y sin ellas.  Material y métodos: Estudio observacional analítico Leer más2017 – Recuento en saliva de Streptococcus mutans en niños de 6 a 12 años con y sin tinciones cromógenas[…]